Functional Annotation
A site may be a:
  • Physiological Site
    A site that has a confirmed physiological role. Each physiological site has an associated function.
    → Show FUNCTIONS
  • Modified Physiological Site
    At least one metal ion has been removed, added or substituted by another metal with respect to the physiological site.
    it may have more than one of this modifications:
    • A physiological metal ion is substituted by another one
      When the position of the native metal ion is filled by another metal without in vivo relevance.
    • A metal ion is removed
      When the physiological metal site has a vacant position (no metal ions occupy the position).
    • A metal ion is added
      When the physiological metal site presents a new position, occupied by an additional metal ion.
  • Not Physiological Site
    A site for which current knowledge suggests that there is no physiological relevance within the cell.
    it may be:
    • Spurious
      The result of a binding event that is observed due to experimental procedures but is not relevant in vivo.
    • Artificial
      The result of a binding event occurring due to engineered or chemical modifications of the macromolecule.
    • Inhibitory
      The result of a binding event induced to inhibit the function of the protein for in vitro studies (the binding does not occur in vivo).
  • Unknown
    The physiological relevance of the site is unknown.
    unknown may be the:
    • Site
      When it is unknown if the site has a physiological relevance.
    • Metal occupancy
      When it is known that the site has a physiological relevance, but it is unknown which metal ion(s) occupies it in vivo.